Depression has been previously linked to both experiencing microaggressions and risky sexual behaviors. The present study sought to investigate the potential mediating effect of depression by testing the effect of microaggressions on depression and risky sexual behavior among a non-clinical sample of African American young adults (N=84; Mage=21). Participants completed a 63-item measure that included the Racial Microaggressions Scale (RMAS), Beck Depression Inventory-II (BDI-II), and three sexual risk-related behaviors: condom use frequency, multiple concurrent sexual partners, and sex while under the influence of drugs or alcohol). \r\n\r\nThe sexual risk-related behaviors were individually regressed onto the RMAS subscales and the total BDI-II depression score. Three of the six RMAS subscales (Low-Achieving/Undesirable Culture factor [LOW]; Sexualization factor [SEX], and Environmental Invalidations factor [ENV]) predicted two of the sexual risk-related behaviors: multiple concurrent sexual partners (LOW p<.05; SEX p<.01; ENV p<.01) and sex under the influence (LOW p<.05; SEX p<.01; ENV p<.05). \r\n\r\nNext, the BDI-II score was regressed onto the RMAS scales. The SEX and ENV subscales significantly predicted BDI-II score (b=.31, p<.01; and b=.25, p=.01). When controlling for the SEX and ENV subscale scores, the BDI-II score significantly predicted each of the sexual risk-related behaviors, (condom use frequency, p=.05; sex under the influence, p=.01; and multiple concurrent sexual partners, p<.01). \r\n\r\nThis demonstrates preliminary evidence of depression mediating the effect of certain types of microaggressions and their relationships to risky sexual behavior. Future research will seek to test a fully-powered mediation model. Practical implications for counselors working with this population are discussed. \r\n\r\n